Should you crushing and mixing medications together, even if they are compatible?

When five or seven medicaments and dietary supplements, verified to be compatible according to the detailed descriptions sheets from the manufacturers, are crushed and mixed, and the resulting powder is blended with, say, honey, is giving to the patient, is the patient getting each of the intended medicaments, or is he getting a new compund of unknown properties that may or may not resemble some of the properties of the individual medicaments?? I am very concerned about this issue. As you know, cement, sand, and water are three very different substances from concrete.
Francisco