I am a Physician and psychiatrist, and my wife was diagnosed with Alzheimer's Disease at 65 years of age. I was aware of her having problems 2+ years earlier. My wife is/was a gifted clinical social worker who is loved by all who know her. Even now, she draws people towards her despite having severe aphasia. I have gone from being a senior clinician who treated Alzheimer's Disease to a loving and grieving caretaker of my girlfriend of 52 1/2 years. Initially, there was a new and different form of intimacy. We had a special kind of closeness, understanding, and collaboration. The inexorable toll that Alzheimer's has exacted during her participation as a subject in two failed treatment studies as well as my own present role as a control subject in a radioactive Tau protein identifier in PET scans study has redefined how we function without a change in our closeness. I hate the illness but wouldn't want to be kept from providing care for my wife. As Pat and Tyler have learned, real caring is a challenge but also incredibly gratifying. That being said, there is nothing glorious about this illness. The longer we live, the greater the likelihood that we will develop dementia increases progressively. If we don't direct more resources towards the early identification and treatment of Alzheimer's disease, global society will bear an impossible financial and emotional burden. I encourage all to take on this cause as if it were personal. I further encourage all people between ages 65 and 85 years of age to contact Brigham and Womens Hospital in Boston in order to the multi-site A4 study that is the first attempt to intervene with at risk individuals before they develop symptoms of Alzheimers. Contact Brainlink@ucsd.edu.