My significant other is really depressed...

Does he have a doctor? I believe he could be helped by an antidepressant. I know there can be side effects but he is likely in a state of mind that is hard to escape from. I have been there. It is a horrible feeling. I can't imagine my life without them. I can get stressed easily yet I can try at times to be positive. I believe the medication helps me. I hope you find a solution

Depression is awful, especially if he feels there's no solution.  Doctor, soon.  Antidepressants might not be needed forever, but an MD or Psych.Dr. can let him know.And yes, men do take them.

Depression is a sneaky illness that sucks the life out of a person. I have suffered one and off from Seasonal Depressive Disorder and I know how challenging it can be to even get out of bed and get dressed.

You cannot 'pull someone of of depression' anymore than you can pull them out of cancer or diabetes. Depression is real, not a choice and can be deadly. When one is overwhelmed by the terrible thoughts flowing through their head and the feelings of worthlessness, a brisk walk and friendly chatter will not cure it.

Medication may help, get him in for a check up and ask for full labs to be done. Some diseases are associated with depression, such as Thyroid imbalance B12 can wreck havoc if it is out of whack too..

For me talk therapy gets me though the winters, but I also know that it will get better in the Spring. Getting outdoors, fresh air and exercise are good, but they are not a cure. As is good healthy food made from real ingredients.

More important are good friends who stand by me, when I need them most but am least able to ask for help. The ones who will be pushy and tell me they are coming over, even thought I would say no. They make me tea, push the mess off the couch and sit with me. Knowing someone cares when I am at my worst means everything.

I have never missed school or work due to depression, I can fake it when out, but I collapse when I get home, the effort is exhausting.

Situational depression will be helped by changing the situation.

Is there someone else in the family who could give you and him some respite? Even for an hour so you and your SO could get out for that walk or even spend an evening out. It might be worth getting a health aide to come in for a few hours. Are you all on your own with Grandpa? Check out respite care for him in a facility and go on a short vacation.

Depression and stress can be the cause of many health issues; high blood pressure, heart problems, stroke, and lots of others. Have you considered a facility for Grandpa?

Grandpa needs a different living arrangement - check out assisted livings or nursing homes.