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Mother in law has COPD and from time to time will accidentally knock the tubing off the oxygen generator. She doesn't notice it until she gets to feeling sick and her blood O2 is way down. Are there any devices that can detect this situation? Is there a better connection method?

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I would call the company that provides the oxygen equipment and ask them for suggestions. All of those techs have hidden talents to work through different difficult scenarios.
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I can understand if the cannula falls out of her nose; that's not unusual. But the only time I've seen the cannula become disconnected from either a stationary or portable concentrator is if the cannula isn't properly secured onto its "plug".

Sometimes it has to be twisted back and forth a bit to ensure that it's secure, but once it's on, it rarely comes off without force. In fact, in my experience, it's usually a bit difficult to remove.

Check to see if it's just sitting on the plug or if it's actually been twisted on and "screwed onto" the plug.
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