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She suffered from extreme anxiety when husband and son died from COVID-19 in April. This anxiety was expressed as knee pain that no amount of pain medication could relieve. The pain was managed when anxiety meds were increased.

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If she was taking opioids, those on their own can cause severe itching. With dementia, there is no rhyme or reason for why a person does anything. You are always just trying to stay one step ahead--frustrating, I know.

I'd go along with a change of anxiety meds. Often those will be enough to deal with a problem that seems to have no underlying cause. Anxiety at any stage of life is awful!
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Have you pursued having the anxiety meds revisited and possible changed or adjusted?
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There are some anti-itch lotions that can help, although they are a little expensive. CeraVe lotion for itch relief helped my mother.
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