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Short of this, let us say the person refuses to cooperate in an exam, if you have evidence that the person lives in unsafe conditions hygiene-wise (mold, dirty diapers, dead or dying animals, hoarding squalor), or if you know the person has been lost, is unsafe to drive, etc. You should call Adult Protective Services and ask that a case file be opened, explaining who you are, why you believe there is a danger.
It isn't enough to say "I don't think granny is a good housekeeper anymore, or granny isn't showering often enough" if you get my meaning.
With so little information from you it is difficult to see what is driving your questions, but I hope I have given you someplace to start.