Is it normal to get frustrated and irritated with my husband?

It's called pseudo bulbar effect...laughing or crying at inappropriate times. Might be what's going on, but I'm more inclined he's trying to keep you at arm's length emotionally. He's in serious trouble, and he knows it.

Please PLEASE don't take it personally. Just try to understand that your husband is in a fight for his life. Support him in whatever way he's comfortable -- and love him to bits and pieces.

My husband laughs at things when he is embarrassed or scared. he just was told at his podiatrist appointment that he had a serious infection inside his ankle...(we thought he had just twisted it, mildly)...and the doctor went off on him, telling him he could lose his foot and his life...well, that got his attention and he stopped joking and laughing. For him (he also has had some strokes) it is a coping mechanism.

You are normal. Hubby is just coping. You should probably stand up, put your hands on your hips and stick your tongue out and/or make a raspberry at him. You can always try to laugh too. It is TOTALLY normal to get frustrated with caregiving when the simplest things go awry.

Laurielle, does hubby start laughing anytime you want to have a serious discussion with him? My sig other does that, it's his way of escaping from having to talk about anything that has to do with our relationship. Irritates me to no end, I usually wind up slamming the door. Then 10 minutes later he acts like nothing happened... but I am ticked off the rest of the day :P

Sig other also takes Percocet for his back, but this annoying frustrating laughing has been his trademark for decades according to his grown children.

Of course it is normal to feel frustrated with the opposite sex and the same sex too. That is just human nature.
Given your husband's condition and prognosis and the inability to continue to lead a normal life. You say he is alone much of the day which I assume means that your are both younger and you have to have the income. Is he still able to drive? are there places he would like to do and activities he might enjoy. He sounds too young for adult day care but are there people he could go fishing with for example, or if he is competitive maybe join a bowling league. If he has a favorite hobby can it be miniturized so he can . One gentleman I knew was able for many months continue to go to the local coffee shop and continue to hang out with his buddys. I am not unsympathetic to your frustration but you have to be the one to begin taking the lead and just making decisions.

There is actually a syndrome of laughing at inappropriate times. I saw a commercial on tv for a medication to help.

That being said, I think that your husband has an awful lot going on in his life and that there would be very little to laugh about. I would be turning cartwheels if I thought I could get him to laugh at me.

However, your question was, is it normal to get frustrated and irritated at your husband. A very resounding YES! You would have to be a saint if you didn't occasionally get frustrated. Maybe you are a sainte anyway. Make him laugh, laughter is the best medicine. Be sure you laugh with him!

A syndrome of laughing at inappropriate times? Are you referring to 'hebephrenic
Schizophrenia?
The laughing behavior is also a symptom of smoking pot, as well as excessive hunger, or having the munchies.
No matter the cause, if someone is constantly laughing at you, that is a sign of disrespect, just like when you speak and they roll their eyes as if to say, what you say, think, or believe is irrelevant and stupid. Walk away.