Just my own experience, but I have taken it for about 2 years now, in conjunction with a nutritional/nutrient approach to depression prescribed by a medical doctor. I feel like it does sort of brighten me up a bit. I am continuing to take it as I feel it does help.
I read years ago that Sam-e has more of a tendency to react with medications than other supplements, especially with anti-depressants. I always tell my PCP if I’m taking anything OTC and if I don’t, she asks. Be careful!
Good luck to you, whatever you decide!