My husband was in surgery for 7 1/2 hours. They removed his colon. He was under the influence of heavy anesthesia for at least twelve hours. That was nearly three years ago. After the surgery his personality changed. He had the soul of a poet before. He was highly intelligent and very articulate. Still is. But now he's more matter-of-fact. Since the surgery, when I try to explain what I mean by something, he thinks I'm arguing. Could being under the influence of those drugs for so long have caused this? His in his upper 60s. His sleep patterns changed.