I was still feeling depressed and anxious 6 months after Mom's passing, so the doctor gave me the generic Zoloft. I'm really sensitive to meds, so I started out with 1/2 pill for 6 days, and have taken one pill (50mg) for the past week. I feel terrible. I have little appetite, wake at 5am and feel shaky inside yet very very tired. Is it worth it to suffer like this to get a good effect in the end? Does the reverse happen when you go off them, even gradually? I'm 70, worry about everything anyway so I'm having a very hard time of it.