Should I wake up my grandmother when she's sleeping at night to change her diaper?

Mom uses pull ups at night. She stays dry but I change her early in the morning.

If you’re asking because gma is soaked in the AM, check the brand of her briefs. Make sure they are the super absorbent overnight ones. You may want to purchase the more expensive ones online and save them for the nighttime. I’ve found that the store brands, especially Depends, aren’t really that absorbent. Also, make sure grandma’s fluid intake stops a few hours before she goes to bed.

Modern incontinence products are designed to wick moisture away from the skin so there shouldn't be any harm in leaving her until morning - you need your sleep as much as she does.