My mother has moderate dementia at age 88. Her doctor suggested Aricept first. I looked into the mechanism of action of the drug and, realizing it increases availability of acetylcholine in the brain, began giving my mother a choline supplement, which made and continues to make a positive difference. Upon reporting this to the doctor, the doctor was skeptical that the choline made any difference, although during that appointment my mother was considerably more coherent and focused than she had been a few weeks prior. We began with the Aricept, which resulted in two days of vomiting. I took her off of it, and she recovered rapidly. Now they (the Dr. and Neurologist) want to try Namenda. My gut/intuition tells me no (as it did for the Aricept). As I am researching, it seems the majority of posts report marginal or negative effects. Any comments/experiences? Thank you.