Certainly happened to me - because I neglected my own medical check-ups - my neurofibromatosis tumours in my spine have become inoperable and I am permanently on a walking frame - and I am only fifty.
The saddest story I have heard was on talkback radio one night a few years ago - a 77 year old daughter was FORCED to be sole carer to her 97 year old mother with severe dementia. Because the selfish mother wanted help from no one but the daughter, the daughter was legally compelled to care for her mother - in spite of the fact she was disabled - and elderly - herself. The time came when the 77 year old daughter needed life-saving surgery - but she was not allowed to have the surgery as it would have meant her mother would have died because of being unable to look after herself - and unwilling to accept outside help.
I personally know a lady somewhere between 60 and 70 about ten or so years ago who was forced to be sole carer to a very elderly mother who very selfishly refused outside help - so this poor daughter was forced, for ten years, to be sole carer to her severely demented mother who was also extremely violent. Finally, the mother died and the daughter finally had her freedom to have her own life and start seeking employment. She got voluntary work. But alas, she got breast cancer and died. The breast cancer was caused by all those ten years of stress.
BTW, I suffered intense stress and abuse from 2002 to late 2014 --- first abuse from my late father who got severe dementia --- and then my mother who got severe dementia after dad died --- my doctors blame that for my now severe neurofibromatosis and eczema.