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Discomfort how. Cramps, aches. My DH suffers from cramps. I have heard not enough water or calcium. If its just aches I take 2 Advil and that seems to help me.
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Many older people wake frequently in the night. They lie awake for an hour or so, then (hopefully) drift back to sleep for a while. It can help to have a list of things to think about – there used to be a special set of prayers for people to ‘think to themselves’ when they woke in the night. I tell myself the plot of a book I’ve recently read or know well.

What is the problem? If it’s that you can’t get enough sleep yourself, you need to think about options for sleeping separately. If it’s that he doesn’t get enough sleep at night, then sleeps a lot during the day, you may need to work on keeping him awake during the day. If he can’t cope with pain (not just discomfort), you need to check out pain medications.

More information would help.
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Don't be afraid of heavy duty pain killers if they have been prescribed. Medical marijuana might also help if it is legal in your state.
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Have you discussed this with his doctors?
There are medications that can help with pain management.
There are medications that will help him sleep through the night,
Is there a reason for the discomfort? Is it pain related? Is it pain from the cancer or other pain? What type of mattress does he have? A good mattress can help a lot.
Many people find it more comfortable to sleep in a reclining chair due to pain.
As Geaton777 has mentioned bit more info might help.
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From your profile:

"I am caring for my husband James, who is 84 years old, living at home with age-related decline, cancer, hearing loss, mobility problems, sleep disorder, stroke, and vision problems.

Apparently he has more than just "vision problems"... your profile says he is blind. Like totally blind? Or legally blind?

"Discomfort" is a very vague description. Is it from his cancer? Are you looking for suggestions to address his sleeping problems or his discomfort? More info would be helpful.
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