Can be up to 10 trips. He is taking 40mg in morning and again at 4pm. If his legs swell, which luckily they haven't lately, he has to take a kicker pill which is just another one I believe. He has been home about 2 weeks from rehab/hospital from stomach bleed and previously a leg infection. He is a fall risk and must be accompanied where ever he goes. My husband and he are getting exhausted from the sleepless nights.