My Mom in Law is on Sinemet for the past couple of months. She is terribly confused regarding time of day. Yesterday she went to her lobby and called me, looking for her son (my husband), and asking why he wasn't picking her up for her appointment that is today. She has trouble with time of day, and now she seems to be having trouble with today and tomorrow. Is this a side affect of the drug, or is it something more serious? My husband says it's the drug, but I am not sure, since she's been on it a couple of months already. How do I get him to be more serious about her condition, rather than being annoyed because it is inconveniencing him? She is not the easiest person, or the most patient herself.