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Blessings
Bridget
The only time it didn't work good was years ago when I did home health. One patient who was in her right mind(sort of) would complain that her pudding, applesauce, etc.. tasted funny and would throw a small fit. So the family suggested that we crushed all her pills and sprinkle them over all her food. So the bitter pill taste wasn't so noticeable. The only downfall was if patient wouldn't eat all of her meal she didn't get all of her meds.
Another suggestion is getting meds from a Compound pharmacy(I think thats what it called) They can turn meds into other forms like lollipops, popsicles or liquid. I always wanted to try this but moms insurance company wouldn't pay the extra cost for service.
There may not be a reason that you can discover. But I think I'd start there, because if you knew the reason she doesn't want to take them that might give you some ideas for how to approach it.
Put them in a cup or in a spoon, feed them to her, give her a drink of water or juice, tell her "Swallow your pills". Then check to make sure she swallowed them. If she has her wits about her, it will annoy her. Do it 3x a day and Expect her to comply. Be consistent, don't back down. Then give her a cookie:)