Can meds help my 87 y/o mom stop having delusions that someone is living in her house with her and wants to kill her?

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We took her to a neuro for testing + MRI was negative. Recently saw a psychiatrist. She is afraid to go back to her home. She called police twice for imaginary person as she fears for her life.

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Risperdal has been effective for my Alz/dementia mother although she still has hallucinations and delusions from time to time. The drug does have to be increased over time and it takes about 6 weeks to reach the right therapeutic dosage - not too much that she is zonked out, not so little it is ineffective. And yes, a UTI is should be checked for. Hopefully someone is always at home with your mother? At this point, if you haven't already, you should bring in caregivers. If your dad is still alive, they can do caregiving during waking hours unless your mother wanders. Setting the burglar alarm can prevent her from getting out of the house at night. Later on she will be up at night and you need 24x7 caregivers or to place her in a memory care facility.
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Has she been checked for a UTI?
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Definitely speak to her Dr. about this and see if there's anything that can be done.

I noticed on your profile that your mom is living in independent living and has Alzheimer's. It might be time to start thinking about another living arrangement. And if the Dr. should prescribe your mom anti-anxiety medication she will be at a higher risk for a fall.

To your mom, what she fears is very real. As I'm sure you know, being told that it's not real or that she is imagining things will not help her feel better or safer. Yet you don't want to validate her fears either. As the Alzheimer's progresses the hallucinations and delusions and paranoia will only get worse. Beginning the process of moving her somewhere where she'll looked after might not be a bad idea.

It must be very frustrating to see your mom so scared and to feel helpless in alleviating her fears. Alzheimer's is such a horrific disease and I'm sorry that your mom has to suffer through it. She's lucky to have you by her side.
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in her last weeks of life my mothers delusional thinking never changed but haldol injections kept the visual hallucinations at a dull roar and kept her sedated enough to shrug off the scary stuff. haldol improved her QOL and this by her own admission.
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