He was ok on 375mg/day regular when he rememberd to take them. On 12hr 400mg/day not so good? My husband (age 70) was okay on a total of 375 mg of regular release when he remembered to take them throughout the day. (For years he had been on a lower dose but the 375 made a great improvement!) Recently he was switched to the kind that releases slowly for 12 hours, with a total of 300mg/day -- soon raised to 400mg/day.
There has been outside stress since the switch (a fender bender, other things) so it is hard to tell, but he seems slightly tense, resentful all day. Does this make sense, when the total dose is higher?
Current timing: 200mg morn and 200mg dinner time - both slow release - 400 total
Recent previous: 150 morn, 150 dinner - slow release - 300 total
Earlier dose was regular: 75+75 morn, 75+75 dinner, 75 night - better effect? but he was having insomnia - 375 total
In a way the highs and lows of the regular dose were easier for me to deal with! If he messed up on timing, he would suddenly get in an unrealistic rage about something, then when he took his next dose he would calm down and see how crazy it had been. Now his resentment is more realistic, about me being generally standoffish and unaffectionate (funniest thing, wonder why!). So he goes on believing it constantly, a week or so so far.