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He's lost lot of weight, is severely jaundiced. Does loss of leg functions play into this?

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Neurologic complications in patients with advancing liver disease can include peripheral neuropathies that lead to ataxia (not walking).
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Our hepatitis expert is, I think, still MIA.

Gloria, do you mean that your brother has suddenly lost the ability to use his legs? - to stand, walk, move them at all, or what?

Is he currently receiving medical attention? Because if so I think you'd better consult his doctors about any new symptoms.
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