That makes it tough. I'd discuss it further with her doctor to see if meds need further adjustment. That sounds like too much. Is she actually going when she goes to the bathroom? Does she do it in the daytime? Has she ever been checked for sleep apnea? I ask, because, sometimes that can also cause a person to get up a lot during the night to urinate. I know, it sounds odd, but, it happened to me. After treatment, it went away. ALSO, I'd check her blood sugar. High blood sugars can also cause frequent urination. I hope you can get this worked out and get some rest.
