My mother in law is in stage 4 renal cancer, she is still taking chemo pills to prolong her life but she is losing weight on a daily basis and in alot of pain. She is 90lbs today. She takes marinol to stimulate her appetite but she keeps losing weight, she has 100mcg/hr fentynol patches but still very uncomfortable. She has lived 6 months longer than the typical case...but no one will give her a prognosis. When do we know it's time to call hospice?