What are the very earliest signs of Alzheimer's? I'm noticing in one relative of mine increased emotional lability, catastrophizing, focusing on the negative to an extreme degree and being illogical and a bit paranoid. These tendencies were always there but they are much worse in the last two years and it is interfering with her ability to make smart decisions about her own healthcare. Refusing to see the doctor for persistent problems because she's paranoid they will be incompetent and won't help her anyway. She's only 60 and still working so she's still very functional. Her mother and grandmother had Alzheimer's and I'm worried about her particularly any early onset of Alzheimer's or dementia. I also will be managing her care along with my mother's and it's one of my greatest fears that I'll have to deal with both at the same time. If I were to talk directly with my relative about what I'm seeing she would just get very defensive and angry but refuse to consider there's any real problem - because only her opinion is valid, but that's always been true, lol. Doctors have tried repeatedly to give her antidepressants but she rejects this out of hand. Thanks you all for your perspectives.