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Can she move to a different place? Or change jobs? What is behind her sadness?
I know I always mention these meetup.com groups, but boy they really help. Just to join a group of your interest puts a person right in the middle of people with the same interest of your own. There are a bunch right in you area I am sure!
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has she been medically evaluated for clinical depression or bipolar II depressive moods swings? What about thyroid problems or some other hormonal imbalance? When was the last time she got a physical?
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