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How long does Alzheimer's disease last on average?

Maurizio Grimaldi, MD, PhD

The sporadic form of Alzheimer’s disease on average, given the state of good supportive care, can last from 5 to 20 years. The average, calculated by the Alzheimer’s Association, is around 8 to 12 years.

In general, there is a phase in which learning and memory performance is mildly compromised. This stage can last as short as few months or as long as a few years. This phase transitions into the next, consisting of severe fading of learning and memory capability that develops over the course of a few years.

Finally, the patient with a fully developed clinical picture of the disease falls into a state in which the sense of self is lost. The familiar, although rare, early onset form of the disease rapidly progresses and rarely the patient survives 8 years from the diagnosis.


Maurizio Grimaldi, MD, Ph.D. is the Leader of the Neuropharmacology/neuroscience Laboratory at Southern Research Institute in Birmingham, Alabama. Dr. Grimaldi graduated from medical school magna cum laude from the University of Napoli in Italy, one of the oldest and most prestigious academic institutions in Italy. Specializing in clinical pharmacology, Dr. Grimaldi obtained his PhD in neuropharmacology and toxicology from the same University. At Southern Research Dr. Grimaldi directs the laboratory of neuropharmacology where he conducts researches on brain physiology and  on novel treatment agents for CNS diseases such as Alzheimer’s and brain tumors. Dr. Grimaldi also directs the commercial activities for the Neuropharmacology Laboratory at Southern Research, including low-throughput screening. He is co-investigator in the NIH-NINDS Drug Screening for Neurodegenerative Diseases and Stroke. In this capacity, he supervises assay transfer from submitting investigators to the high-throughput screening facility. Visit him at www.SouthernResearch.com.

Comments (1 to 5 of 11)

Bennie said
Jan 15, 2009

Mother is to the point of forgetting names and such. She was put in a health and rehab home due to foot swelling. She ask me the other day "where am I and why am I here. I try to tell her the truth knowing she will not remember,but I'll say mom you won't remember what I tell you but in the here and now maybe you will and that is ok for now. I did not agree to this place but two of my sisters do not want to deal with her anymore and I have no say so. For the last 4 years I have cared for her everyday while everyone else worked. I was voted into this because I had the least bills and my child is grown and on his own. You know the old saying... you leave the room to go to the restroom and return finding out you have been choosen for who knows what... Well I would not trade the years I have had with mother. I think the other sisters disliked me because mother and I were so close and when she needed something when she was with one of them she asked for me.I miss her so but can hold my head up and know I did my best and my mother somewhere deep down knows I love her. Bennie

mary79 said
Jan 24, 2009

my dad was diagnosed with dementia at the age of 56.He was always a bit forgetful as we were groing up and over the years this progresed slowley.At the age of 54 he started to get worse at this stage we got medical help.He was addmited to the local dementia ward .My father is now 62 and his dementia has progresed at a rapid speed.He is in the last stage of alzheimers and in full time care.I know how hard this is to deal with and would advise you and your family to seek all the help you can.There is only so much that you can offer at home but a lot more is needed.Alzheimers is a very long and suffering illness that effects the whole family .

AnnieKinsey said
Feb 18, 2009

AD certainly is a disease that affects not just the patient, but the whole family. And each individual within the family structure will deal with the disease differently. Some will not "want to be bothered" and others will give and give until they are "used up." I have been caring for my father in home since his onset about seven (7) years ago. He is now on hospice care and at n-stage of the disease. I would not trade these past few years for anything. It has been hard, yes certainly

Bennie said
Feb 18, 2009

I went to the h/rehab to see mother fri before valentines day and took her a heart of candy,she cried and said you remembered me. Of course I started crying again(crying now).Mom said I want to go home with you and I had to tell her again mama I can't do that. She smiled at me and said I know. My best friend told me that my sisters are not happy with their lives so they do not want anyone else to be happy. I believe they are just cruel hateful people. One day they will be old and are afraid this will happen to them. I believe mom is going into another stage of dementia and when I visit again she my not remember me at all. She can remember to ask for a cold coke when I visit next. I bring one no matter what. Even with out mom in my home anymore this still hurts and takes its toll on my health. Just like you AnnieK. I would not trade these years for anything . I have memories no one else will have. Bennie

Anne said
Feb 18, 2009

It has been a little over a year since I became involved full-time in my parent's lives. Our relationship was always peripheral before that, from the time I was a teen or maybe before. I wanted more, but one was too busy, and the other too mean. Now Dad's changing and fading. We went through the anger stage, and a confused stage, and now it's a tangled stage. Everything he says comes out different than what it should. He's not eating most of the food offered, and won't get out of bed much. Only 8 months ago he was still driving. But he got lost, and wandered, too. The decline has been incredibly rapid. I'm preparing myself for the end already, but have no idea what to expect from one day to the next. I can't imagine going on like this for long. He refuses to shower or brush his teeth or eat. He can't button or zip or dress anymore. Wow. It makes me wonder if the progression will continue at such a fast pace. It's sad, but what does he have to look forward to? He doesn't seem upset, and he's not angry anymore. Whew! (That was awful!) For awhile he seemed incredibly sad. Now, he just wants to stay in bed, and not get up, and not do anything. Not depressed, I don't believe, but just unable. Too much effort or too much stimulation for him to do anything. Weird. I couldn't imagine being so immobile. I think I'm already preparing for the inevitable. I'm not sad or grieving right now, like I have been. In fact, I can't understand why not. But why sit around all sad? Everyone dies of something. I can't change this. And we do try to enjoy what we can with him. It's limited. I rejoice that I get to spend time with him whenever I want. He can't get away from me. He's stuck. And I don't have to share, cuz no one else is around. So I've been blessed. But, I do have life outside of Dad. And a young son to raise and a husband to love. Both are involved in Dad's life, so we all have each other today. Truthfully, I hope I don't have to watch a slow, agonizing, painful decline. Withering away, unable to respond. That would be hard to participate in for long. Fortunately, friends and family stay updated daily through a Care Pages website I created back in October when Dad was hospitalized. They consistently view his web pages and have been and incredible encouragement to me. I have been blessed. It will probably hurt like crazy when Dad does go, but sometimes I think, that would be better than living without purpose. Am I rambling or what?

If I had a choice, I'd have the Dad back who loved to participate in all sorts of activities, and could talk to me normally again. But that is not to be. Perhaps I'm just learning to accept what can't be changed. And to hope it won't get worse. But there's no way to guess how long the process will take. Best to just take things one day at a time. Just for today, I want to be a blessing. Not a hero, just a blessing. A smile. A touch. Love. And be grateful for today.

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